The protection of fattening pigs against foot and mouth disease with an oil-adjuvanted vaccine : Studies on South American FMD virus strains

The performance of a trivalent oil-adjuvanted FMD vac­ cine formulated with O1 Campos, A24 Cruzeiro and C3 Indaial FMD antigens has been evaluated in fattening pigs in Brazil. As previously demonstrated, a single dose of this type of vaccine injected at the time of weaning induced a rapid onset of protection against challenge and a protracted immunity lasting at least for four months, i.e. the usual life span of fattening pigs. No general or local clinical signs occur after vac­ cination by the intramuscular or intraperitoneal routes. Some of the animals inoculated intramuscularly had residual tissue reactions at the time of slaughter but these could be dissected off the carcass with the loss of only a small (100 to 200 g) portion of muscle tissue. Intraperito­ neal inoculation was not associated with residual lesions affecting the carcass.